How NF-κB is activated: the role of the IκB kinase (IKK) complex
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چکیده
منابع مشابه
The IκB Kinase Complex (IKK) Contains Two Kinase Subunits, IKKα and IKKβ, Necessary for IκB Phosphorylation and NF-κB Activation
of the NF-B dimer which then translocates to the nucleus to activate gene transcription. In the case of IB␣ the inducible phosphorylation sites were mapped to ser-ines (S) 32 and 36, whose substitution with alanines (A) or threonines (T) prevents phosphorylation, ubiquitination Summary was recognized that the key step in NF-B activation is IB phosphorylation, much of the effort to understan...
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The IκB kinase (IKK) complex is the signal integration hub for NF-κB activation. Composed of two serine-threonine kinases (IKKα and IKKβ) and the regulatory subunit NEMO (also known as IKKγ), the IKK complex integrates signals from all NF-κB activating stimuli to catalyze the phosphorylation of various IκB and NF-κB proteins, as well as of other substrates. Since the discovery of the IKK comple...
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(Baeuerle and Baltimore, 1996). More than a decade ago, the transcriptional activator In vivo, phosphorylation of IkB occurs when it is comNF-kB was described as a protein that bound to a speplexed with NF-kB and does not cause dissociation of cific DNA site in the intronic enhancer of the immunothe complex. Rather, it signals ubiquitination of IkB, globulin k light chain gene (Sen and Baltimor...
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The IKK [inhibitor of NF-κB (nuclear factor κB) kinase] complex has an essential role in the activation of the family of NF-κB transcription factors in response to a variety of stimuli. To identify novel IKK-interacting proteins, we performed an unbiased proteomics screen where we identified TfR1 (transferrin receptor 1). TfR1 is required for transferrin binding and internalization and ultimate...
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ژورنال
عنوان ژورنال: Oncogene
سال: 1999
ISSN: 0950-9232,1476-5594
DOI: 10.1038/sj.onc.1203219